Abstract
BOTH Mannik and Kunkel1 and Fahey2 have shown that there are two antigenic types of human γ-globulin, which differ in their light chains. Type I light chain bears the antigenic determinant characteristic for Bence–Jones protein group I—the same holds for type II light chains and the Bence–Jones protein group II antigenic determinant. With some antisera, the immunoelectrophoretic pattern of human γ-globulin shows two precipitin lines: these lines are parallel and approximately of equal length; one corresponds to type I γ-globulin, the other to type II.
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References
Mannik, M., and Kunkel, H. G., J. Exp. Med., 91, 438 (1963).
Fahey, S. L., J. Immunol., 91, 438 (1963).
Dray, S., Science, 132, 1313 (1960).
Lichter, E. A., and Dray, S., J. Immunol., 92, 91 (1964).
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BURTIN, P. A Third Antigenic Type of Human γ-Globulin. Nature 202, 1019 (1964). https://doi.org/10.1038/2021019a0
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DOI: https://doi.org/10.1038/2021019a0
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