Abstract
TREMOBINE, 1-4-dipyrrolidin-1-yl-but-2-yne (I) is a substance which was originally shown by Everett1 to produce generalized tremor and some rigidity accompanied by marked parasympathetic stimulation in a wide variety of animals. These effects are antagonized by drugs effective in the treatment of Parkinson's disease in man, and Ahmed and Marshall2 found that with anti-Parkinson drugs there was a correlation between the clinically effective dose and the ability of the compound to inhibit the tremor produced by tremorine in mice.
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References
Everett, G. M., Blockus, L. E., and Shepperd, I. M., Science, 124, 79 (1956).
Ahmed, A., and Marshall, P. B., Brit. J. Pharmacol., 18, 247 (1962).
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Schwartz, D. G., Burkard, W. P., Roth, M., Gey, K. F., and Pletscher, A., Arch. int. Pharmacodyn., 141, 135 (1963).
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LESLIE, G., MAXWELL, D. Inhibition of Tremorine by a Group of Non-anti-Parkinson Phenothiazine Derivatives. Nature 202, 97–98 (1964). https://doi.org/10.1038/202097a0
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DOI: https://doi.org/10.1038/202097a0
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