Abstract
THE hepatopancreas is the primordial homeostatic organ in a large number of species in which the kidney has not as yet developed. In the mammalian embryo, the hepatopancreatic primordium evolves earlier than the metanephric ones1. The liver and the pancreas of adult mammals and man are the successors of the ancient hepatopancreas. The question arose whether these successors maintain their primordial homeostatic adequacy even in a species which has fully developed kidneys.
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References
Arey, L. B., Developmental Anatomy: A Textbook and Laboratory Manual of Embryology, fifth ed. (W. B. Saunders Co., 1948).
Cotzias, G. C., in Mineral Metabolism: An Advanced Treatise, 2 Part B, 403 (Academic Press, New York, 1962).
Underwood, E. J., Trace Elements in Human Nutrition, second ed., 187 (Academic Press, New York, 1963).
Maynard, L. S., and Cotzias, jun., G. C., Biol. Chem., 214, 489 (1955).
Chappell, J. B., and Greville, G. D., Fred. Proc., 22, 526 (1963).
Greenberg, D. M., Copp, D. H., and Cuthbertson, E. M., J. Biol. Chem., 147, 749 (1953).
Burnett, jun., W. T., Bigelow, R. R., Kimball, A. W., and Shepard, C. W., Amer. J. Physiol., 168, 620 (1952).
Cotzias, G. C., and Greenough, J. J., J. Clin. Invest., 37, 1298 (1958).
Cotzias, G. C., Borg, D. C., and Selleck, B. H., Amer. J. Physiol., 202, 359 (1962).
Cotzias, G. C., Borg, D. C., and Selleck, B. H., Amer. J. Physiol., 201, 927 (1961).
Papavasiliou, P. S., and Cotzias, G. C., Fed. Proc., 20, 295 (1961).
Cotzias, G. C., and Papavasiliou, P. S., Nature, 195, 823 (1962).
Cotzias, G. C., Borg, D. C., and Bertinchamps, A. J., in Metal Binding in Medicine, 50 (Lippincott, Phil., 1960).
Hughes, E. R., and Cotzias, G. C., Amer. J. Physiol., 201, 1061 (1961).
Papavasiliou, P. S., and Cotzias, G. C., J. Biol. Chem., 236, 2365 (1961).
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COTZIAS, G., PAPAVASILIOU, P. Primordial Homeostasis in a Mammal as shown by the Control of Manganese. Nature 201, 828–829 (1964). https://doi.org/10.1038/201828a0
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DOI: https://doi.org/10.1038/201828a0
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