Abstract
BOTH direct agglutination and inhibition techniques1–4, utilizing red blood cells coated with human and rabbit 7S γ-globulin, have been used in investigations of the reactivity of rheumatoid factor. The findings are consistent in indicating that the 19S rheumatoid factor molecule combines with that part of the 7S γ-globulin molecule equivalent to the papain digestion piece III of Porter5.
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References
Oikawa, T., clin. Res., 9, 24 (1961).
Cohen, E., Nature, 190, 552 (1961).
Franklin, E., Rep. Tenth Intern. Cong. Rheumatology, Rome (September 1961).
Goodman, J., Proc. Soc. Exp. Biol. (N.Y.), 106, 822 (1961).
Porter, R. R., Biochem. J., 73, 119 (1959).
Epstein, W. P., Johnson, A., and Ragan, C., Proc. Soc. Exp. Biol. (N.Y.), 91, 235 (1956).
Fleischman, J. B., Pain, R. H., and Porter, R. R., Arch. Biochem., Supp. 1, 174 (1962).
Porter, R. R., Symp. Basic Problems in Neoplastic Disease, edit. by Gellhorn, A., and Hirschberg, E. (Columbia Univ. Press, 1962).
Edelman, G. M., and Benacerraf, B., Proc. U.S. Nat. Acad. Sci., 48, 1035 (1962).
Porter, R. R., and Press, E. M., Ann. Rev. Biochem., 31, 625 (1962).
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HENNEY, C., STANWORTH, D. Reaction of Rheumatoid Factor with the Isolated Polypeptide Chains of Human 7S γ-Globulin. Nature 201, 511–512 (1964). https://doi.org/10.1038/201511a0
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DOI: https://doi.org/10.1038/201511a0
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