Abstract
DURING recent years, organic N-nitroso compounds have been found a new class of very effective carcinogenic substances. Nitrosamines and nitrosamides in high yields produce malignant tumours selectively in liver1–3, lungs4,5, fore-stomach6,7, œsophagus8, bladder9, kidney4,10, and nasal sinuses11 in several animal species, depending on chemical structure, mode of application and dosage of nitroso compound. Localization and histological structure of tumours correspond closely with the situation known in human pathology.
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PREUSSMANN, R., DAIBER, D. & HENGY, H. A Sensitive Colour Reaction for Nitrosamines on Thin-layer Chromatograms. Nature 201, 502–503 (1964). https://doi.org/10.1038/201502a0
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DOI: https://doi.org/10.1038/201502a0
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