Abstract
WHILE performing investigations on the intra-leucocytic survival of Candida, we found that Candida tropicalis survived in whole human blood but Candida albicans did not. Results were similar for cell-free plasma and serum. In these investigations, 0.1 ml. of an inoculum of 107 Candida cells was added to 1 ml. of serum or plasma in siliconized tubes. The Candida-serum mixture was rotated at 37° C for 24 h. At 0, 6, and 24 h, Candida populations were determined by pour plate enumeration techniques. The serum was considered lethal for Candida if fungal census was reduced at least 10-fold at the 6- or 24-h periods when compared with the 0-h count.
Similar content being viewed by others
Article PDF
References
Lorincz, A. L., Priestley, J. O., and Jacobs, P. H., J. Invest. Dermat., 31, 15 (1958).
Roth, F. J., and Goldstein, M. I., J. Invest. Dermat., 36, 383 (1961).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
LOURIA, D., BRAYTON, R. A Substance in Blood Lethal for Candida albicans. Nature 201, 309 (1964). https://doi.org/10.1038/201309a0
Issue Date:
DOI: https://doi.org/10.1038/201309a0
This article is cited by
-
Ureteral blockage by Candida in a patient with urinary derivation type Camey
International Urology and Nephrology (1989)
-
The in vitro interactions of candida albicans with nonspecific serum proteins
Mycopathologia (1978)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.