Abstract
INJECTION of anti-rat-liver serum into rats led to the induction of liver tumour, whereas the injection of anti-serum against 3′-methyl-4-dimethylaminoazobenzene (3′-DAB)-treated rat liver failed to produce any such tumour1. It was postulated that repeated exposures to tissue specific antisera might have induced adaptive loss of tissue specific antigen with malignancy as an essential consequence. It was also thought that the tissue specific antigen was modified by haptenic binding with 3′-DAB, making the antibody against it innocuous to normal liver. The present investigation was undertaken to examine the nature of localization of antibodies against normal and 3–-DAB-treated rat liver, in the liver and other tissues of both normal and 3′-DAB-treated rats.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Green, H. N., Nature, 192, 1201 (1961).
Mansi, W., Nature, 181, 1289 (1958).
Nairn, R. C., Fluorescent Protein Tracing (E. and S. Livingstone, Ltd., Edinburgh and London, 1962).
Ghose, T., Nairn, R. C., and Fothergill, J. E., Nature, 196, 1108 (1962).
Nairn, R. C., Richmond, H. G., McEntegart, M. G., and Fothergill, J. E., Brit. Med. J., ii, 1335 (1960).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GREEN, H., GHOSE, T. Localization of Liver Specific Antibody in Normal and 3&′-DAB-treated Rats. Nature 201, 308–309 (1964). https://doi.org/10.1038/201308a0
Issue Date:
DOI: https://doi.org/10.1038/201308a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.