Abstract
RECENT investigations in this laboratory with the perfused guinea pig lung have shown that a broncho-constriction, accompanied by histamine release, follows injection into the perfusate of soluble antigen–antibody (Ag–Ab) complexes prepared in antigen excess. It is known that soluble Ag–Ab complexes produce an increase in capillary permeability when injected subcutaneously in unsensitized animals1, and an anaphylactic syndrome when given intravenously2. They have also been shown to induce a contraction of guinea pig ileum in vitro3.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Ishizaka, K., and Campbell, D. H., J. Immunol., 83, 116 (1959).
Germuth, F. G., and McKinnon, G. E., Johns Hopkins Hosp. Bull., 101, 13 (1957).
Trapani, I. L., Garvey, J. S., and Campbell, D. H., Science, 127, 700 (1958).
Kruse, H., and McMaster, P. D., J. Exp. Med., 90, 425 (1949).
Arunlakshana, O., and Schild, H. O., Brit. J. Pharmacol., 14, 48 (1959).
Halpern, B. N., Liacopoulos, P., Liacopoulos, M., and Binaghi, R., C.R. Soc. Biol., Paris, 247, 1798 (1958).
Mongar, J. L., and Schild, H. O., J. Physiol., 145, 46, P (1959).
Schild, H. O., Quart. J. Exp. Physiol., 26, 165 (1936).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BRODER, I., SCHILD, H. Bronchoconstrictor Effects of Soluble Antigen–Antibody Complexes in Isolated Lung, and their Inhibition by Normal Serum. Nature 201, 1137–1138 (1964). https://doi.org/10.1038/2011137a0
Issue Date:
DOI: https://doi.org/10.1038/2011137a0
This article is cited by
-
Changes in the membrane potential and tone of smooth muscle during allergic reactions in the absence of mast cells
Bulletin of Experimental Biology and Medicine (1966)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
