Abstract
WHEN urine of normal adults to whom phenoxymethyl penicillin (penicillin V (200 mg)) had been administered was chromatographed1, a second inhibition zone in addition to the penicillin V zone was observed (Fig. 1). The RF value of this product was identical with that of p-hydroxyphenoxymethyl penicillin, obtained from a sample of crude penicillin V2. This metabolite represents about 10 per cent of the activity found in the urine.
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Brewer, G. A., and Johnson, M. J., App. Microbiol., 1, 163 (1953).
De Flines, J., Waisvisz, J. M., Hoette, I., and Struyk, A. P., Antibiotics and Chemother., 7, 497 (1957).
Behrens, O. K., Corse, J., Jones, R. G., Mann, M. J., Soper, Q. F., Van Abeele, F. R., and Chang, M. C., J. Biol. Chem., 175, 751 (1948).
Reio, L., J. Chromatogr., 1, 338 (1958).
Moser, C. M., J. Amer. Chem. Soc., 72, 1413 (1950).
Bischoff, C. A., and Frœlich, E., Ber., 40, 2791 (1907).
Bray, H. G., Thorpe, W. V., and White, R., Biochem. J., 46, 271 (1950).
Orr, C. H., and Callen, J. E., J. Amer. Chem. Soc., 80, 249 (1958).
English, A. R., Huang, H. T., and Sobin, B. A., Proc. Soc. Exp. Biol. Med., 104, 405 (1960).
Rolinson, G. N., and Batchelor, F. R., Antimicrobial Agents and Chemother., 654 (1962).
Rollo, I. M., Somers, G. F., and Burley, D. M., Brit. Med. J., i, 76 (1962).
Vanderhaeghe, H., Van Dijck, P., Claesen, M., and De Somer, P., Antimicrobial Agents and Chemother., 581 (1961).
Nayler, J. H. C., Long, A. A. W., Brown, D. M., Acred, P., Rolinson, G. N., Batchelor, F. R., Stevens, S., and Sutherland, R., Nature, 195, 1264 (1962).
Williams, R. T., Detoxication Mechanisms (Chapman and Hall, London, 1959).
Walkenstein, S. S., Chumakow, N., and Seifter, J., Antibiotics and Chemother., 4, 1245 (1954).
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VANDERHAEGHE, H., PARMENTIER, G. & EVRARD, E. Identification of p-Hydroxyphenoxymethyl Penicillin as a Metabolite of Phenoxymethyl Penicillin. Nature 200, 891 (1963). https://doi.org/10.1038/200891a0
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DOI: https://doi.org/10.1038/200891a0
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