Hydrolysis of the Phosphorothioate Ion catalysed by Silicone Grease

Abstract

WHEN preparing trisodium phosphorothioate from thiophosphoryl chloride and sodium hydroxide at 80° according to Åkerfeldt¹, it was observed that the yields became much smaller when the ground-glass joints of the apparatus used had been treated with silicone grease. In fact, in some cases no trisodium phosphorothioate could be isolated from the reaction mixture. In these instances liberal amounts of silicone grease had been used in lubricating the glass joints.