Abstract
TRYPAN blue has long been known to possess teratogenic properties1. Several years ago Barber2 reported being able to distinguish mouse fœtuses heterozygous for anophthalmia from those which were homozygous normals by the higher incidence among the former of eye defects in response to trypan blue administered to their dams as a teratogenic agent. All cases of defective eye development were unilateral anophthalmia; the expectation, in the absence of the teratogen, was complete bilateral normality. The anophthalmic mutant has been described in detail elsewhere3,4.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Gillman, J., Gilbert, C., and Gillman, T., S. Africa J. Med. Sci., 13, 47 (1948). Hamburgh, M., Anat. Rec., 119, 409 (1954).
Barber, A. N., Amer. J. Ophthalmol., 44, 94 (1957).
Beck, S. L., J. Hered., 54, (1) in the press; Amer. Zool., 2, 391 (1962) Amer. Zool., 1, 436 (1961); thesis, Brown University (1960).
Chase, H. B., and Chase, E. B., J. Morph., 68, 279 (1941). Chase, H. B., Genetics, 27, 339 (1942); J. Comp. Neur., 83, 121 (1945).
Beck, S. L., Genetics, 47, 942 (1962).
Beck, S. L. (in preparation).
Grüneberg, H., The Genetics of the Mouse, second ed. (Martinus Nijhoff, The Hague, 1952).
Snedecor, G. W., Statistical Methods, fifth ed. (Iowa State College Press, Ames, 1956).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BECK, S. Frequencies of Teratologies among Homozygous Normal Mice compared with hose Heterozygous for Anophthalmia. Nature 200, 810–811 (1963). https://doi.org/10.1038/200810b0
Issue Date:
DOI: https://doi.org/10.1038/200810b0
This article is cited by
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
