Abstract
IN the course of experiments designed to examine the effect of serum on the streptolysin-S susceptibility of tanned erythrocytes1, guinea pig erythrocytes treated with tannic acid in the cold were suspended in 1 : 100 dilution of fresh serum from tuberculous guinea pig. A heavy hæmagglutination appeared a few minutes after mixing. No such heavy agglutination was observed either with heat-inactivated tuberculous serum or with fresh serum of normal animals. These observations led us to further investigations on this curious hæmagglutination phenomenon, provisionally designated as ‘tanned erythrocyte (TE-)agglutination’ to differentiate it from the Boyden's antigen–antibody hæmagglutination2.
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References
Ito, R., Matsuda, M., and Aoki, K., Jap. J. Pharmacol., 9, 169 (1960).
Boyden, S. V., J. Exp. Med., 93, 107 (1951).
Gordon, J., Whitehead, H. R., and Wormall, A., Biochem. J., 20, 1028 (1926).
Wardlaw, A. C., and Pillemer, L., J. Exp. Med., 103, 553 (1955).
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ITO, R., AKIYAMA, M. A Hæmagglutination Phenomenon between Tanned Erythrocytes and Sera of Guinea Pigs. Nature 200, 791–793 (1963). https://doi.org/10.1038/200791b0
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DOI: https://doi.org/10.1038/200791b0
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