Abstract
As Tait et al.1 have pointed out, the half-life of aldosterone in plasma does not reflect metabolism alone. The calculated ‘volumes of distribution’ for the body compartments exceed that of total body water, suggesting that aldosterone is selectively taken up by some region of the body2. The work recorded here shows that injected tritiated aldosterone is unevenly distributed in the various tissues, that the rate of its disappearance from the tissues varies, and that in the liver the radioactivity is found predominantly in the supernatant fraction.
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SULYA, L., McCAA, C., READ, V. et al. Uptake of Tritiated Aldosterone by Rat Tissues. Nature 200, 788–789 (1963). https://doi.org/10.1038/200788b0
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DOI: https://doi.org/10.1038/200788b0
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