Abstract
THE active transport of sodium by the urinary bladder of the toad, Bufo marinus, is increased when the animal1 or the membrane itself2–4 is treated with aldosterone. Antidiuretic hormone also increases active sodium transport by the isolated toad bladder5 ; this hormonal stimulation has been ascribed to a facilitated passive movement of sodium from the incubation solution on the mucosal side into the epithelial cells of the membrane6 ; as a result, there is an increase of that fraction of tissue sodium concerned with the transfer of this ion across the preparation. Hence the acceleration of the active extrusion of sodium, at the serosal border of the epithelial cells, can be taken as a mere consequence of an increased concentration of substrate—namely sodium—made available to the ‘pump’.
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CRABBÉ, J. Site of Action of Aldosterone on the Bladder of the Toad. Nature 200, 787–788 (1963). https://doi.org/10.1038/200787a0
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DOI: https://doi.org/10.1038/200787a0
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