Abstract
THE presence of a number of viruses has been demonstrated visually in the central nervous system of experimentally infected animals as well as in encephalitic human brain. Noyes1 was first to reveal by immuno-fluorescence the presence of West Nile virus both in sensory and motor neurones of mice. Sabin and Messore2, also with the aid of immuno-fluorescent technique, observed herpes simplex virus in the paraffin sections of a human brain, cut from blocks stored over a period of years. Using electron microscopy, Nelson, Hager and Kovács3,4 found crystals of Columbia SK virus, both in neurones and polymorpho-nuclear leucocytes of infected mouse brain. By similar means, yellow fever virus was observed in Bergold's laboratory5 to be associated exclusively with astrocytes of the brain of the mouse.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Noyes, W. F., J. Exp. Med., 102, 243 (1955).
Sabin, A. B., and Messore, G., in Van Bogaert, Encephalitides, 621 (Elsevier Pub. Co., Amsterdam, 1961).
Nelson, E., Hager, H., and Kovács, E., J. Biophys. Biochem. Cytol., 8, 825 (1960).
Nelson, E., Hager, H. and Kovács, E., Science, 139, 499 (1963).
Bergold, G. H., and Weibel, J., Virology, 17, 554 (1962).
Fraser, K. R., in Nairn, Fluorescent Protein Tracing, 161 (Livingstone, Ltd., Edinburgh and London, 1962).
Current Literature of Poliomyelitis: a Periodic Review of the World Literature (The National Foundation, New York, 1949–1963).
Lépine, P., Croissant, O., and Wyckoff, R. W. G., Ann. Inst. Pasteur, 90, 13 (1956).
Buckley, S. M., Arch. ges. Virusforsch., 8, 388 (1956).
Bodian, D., in Rivers and Horsfall, Viral and Rickettsial Infections of Man, third ed., 479 (Lippincott Co., Philadelphia, 1959).
Stuart, D. C., and Fogh, J., Exp. Cell Res., 18, 378 (1959).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
KOVÁCS, E., BARATAWIDJAJA, R. & LABZOFFSKY, N. Visualization of Poliovirus Type III in Paraffin Sections of Monkey Spinal Cord by Indirect Immuno-fluorescence. Nature 200, 497–498 (1963). https://doi.org/10.1038/200497a0
Issue Date:
DOI: https://doi.org/10.1038/200497a0
This article is cited by
-
Ultrastructural studies on the pathogenesis of poliomyelitis in monkeys infected with polivirus
Acta Neuropathologica (1984)
-
Studies on the pathogenesis of and propagation of enterovirus 71 in poliomyelitis-like disease in monkeys
Acta Neuropathologica (1982)
-
Neue Gesichtspunkte zur Frage der Entstehung und der pathogenetischen Bedeutung der entz�ndlichen Reaktion bei Virusinfektionen des ZNS
Archiv f�r Psychiatrie und Nervenkrankheiten (1970)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
