Abstract
THE adult and juvenile forms of the liver fluke differ in their susceptibilities to a number of anthelmintics1. If it is assumed that anthelmintic drugs exert their effects by acting on enzymes or multiple enzyme systems in the parasite then the adult and immature fluke may not possess identical patterns of metabolism. Some of the pathways of intermediary metabolism in the adult fluke have recently been studied using substrates labelled with carbon-14 in conjunction with chromatographic and autoradiographic techniques for the separation of the labelled intermediates formed2. In the present work, a comparison has been made of the patterns of incorporation of radioactivity from carbon-14-labelled glucose, acetate and succinate into the soluble metabolic intermediates of adult and immature forms of Fasciola hepatica.
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References
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WILLIAMS, J., BRYANT, C. Intermediary Metabolism in the Immature Liver Fluke, Fasciola hepatica L.. Nature 200, 489 (1963). https://doi.org/10.1038/200489a0
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DOI: https://doi.org/10.1038/200489a0
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