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Anticoagulant Action of Adenosine Triphosphate

Abstract

THE observation of Pilgeram1 that adenosine triphos-phate (ATP) inhibits the coagulation of blood is especially interesting in that it links the latter process with a key compound of energy metabolism. Pilgeram concluded “the principal site of the ATP action to be on a thrombo-plastin precursor”, but he did not intimate what the precursor might be.

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References

  1. Pilgeram, L. O., Nature, 199, 708 (1963).

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  2. Quick, A. J., Ann. Int. Med., 55, 201 (1961).

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  3. Quick, A. J., Hemorrhagic Diseases (Lea and Febiger, Philadelphia, 1957).

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  4. Quick, A. J., and Stefanini, M., Amer. J. Phvsiol., 160, 572 (1950).

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  5. Quick, A. J., The Hemorrhagic Diseases and the Physiology of Hemostasis, 103 (Charles C. Thomas, Springfield, Illinois, 1942).

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QUICK, A. Anticoagulant Action of Adenosine Triphosphate. Nature 200, 469–470 (1963). https://doi.org/10.1038/200469a0

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  • DOI: https://doi.org/10.1038/200469a0

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