Abstract
IN a previous communication1 we described the accumulation of a large amount of oxytetracycline related to the bactericidal action in the cells of E. coli. This accumulation seemed to be dependent on an energy-yielding system, since the presence of glucose was needed for the accumulation of oxytetracycline, and inhibitors such as 2,4-dmitrophenol and sodium azide inhibited the accumulation at low concentrations at which oxidation of glucose by the resting cells was not inhibited. However, recently, multiple drug-resistant bacteria have been found by many Japanese workers and many biochemical and genetic studies on these bacteria have been carried out2–6.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Arima, K., and Izaki, K., Nature, 200, 192 (1963).
Ochiai, K., et al., Nihon Iji Shimpo, 34, 1861 (1959).
Akiba, T., et al., Nihon Iji Shimpo, 45, 1866 (1960).
Mitsuhashi, S., et al., Japanese J. Exp. Med., 30, 301 (1960).
Nakaya, R., et al., Biochem. Biophys, Res. Comm., 3, 654 (1960).
Watanabe, T., and Fukasawa, T., J. Bact., 81, 669 (1961).
Yokota, T., and Akiba, T., Medicine and Biol. (Tokyo), 58, 172 (1961).
Okamoto, S., and Mizuno, D., Nature, 195, 1022 (1962).
Spott, C. R., and Stanier, R. Y., Nature, 192, 633 (1961).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
IZAKI, K., ARIMA, K. Disappearance of Oxytetracycline Accumulation in the Cells of Multiple Drug-resistant Escherichia coli. Nature 200, 384–385 (1963). https://doi.org/10.1038/200384a0
Issue Date:
DOI: https://doi.org/10.1038/200384a0
This article is cited by
-
Microbiological Transformation of Oxytetracycline
Nature (1966)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
