Abstract
IN a series of observations on about 5,000 rabbits, it was found that they could be divided into 3 groups according to their low-, medium- or high-temperature reactions to intravenous injection of a standard dose of sodium nucleinate (Merck and Co. Inc., U.S.A.; sodium salts of the acids from yeasts)1,2. In later experiments there was found to be a good correlation between the thermal reactions of individual rabbits to the pyrogen and the intensity of anaphylactic reactions, the measurement of the rise in temperature being determined during the anaphylactic reactions3.
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References
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CHIOSA, L., MUNTIU, N., CONSTANTINESCU, C. et al. Correlation between the Reaction of Horses to a Pyrogen and their Immunological Responses in Antitetanic Serum Production. Nature 200, 286–288 (1963). https://doi.org/10.1038/200286b0
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DOI: https://doi.org/10.1038/200286b0
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