Abstract
SINCE Skou's1,2 description of a sodium–potassium-activated adenosine triphosphatase in crab nerve, many reports have indicated that this enzyme has properties virtually identical to those exhibited by the Na+ extrusion mechanism in many tissues3–8. The intracellular concentrations of Na+ and K+ ions are of importance in regulating cell membrane excitability in nerve, muscle9, secretory cells, etc. It is also known10 that the amount of this enzyme in sheep erythrocyte membranes correlates with the intracellular concentration ratio of K+/Na+, which is in turn regulated by a gene11.
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References
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SEEMAN, P., O'BRIEN, E. Sodium – Potassium-activated Adenosine Triphosphatase in Schizophrenic Erythrocytes. Nature 200, 263–264 (1963). https://doi.org/10.1038/200263a0
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DOI: https://doi.org/10.1038/200263a0
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