Abstract
THE implication of lipids in the production of hyper-coagulability of the blood has been recognized for a number of years. For example, the presence of certain lipid fractions has been shown to facilitate blood clotting in vitro, and hypercoagulability has been demonstrated in blood taken from human subjects after a meal of high fat content1–3. It has been shown recently that the addition of certain fatty acids to plasma accelerates the clotting time4, and of especial interest are observations by Poole and Connor that small quantities of long-chain saturated fatty acids, but not unsaturated congeners, evoke a marked hypercoagulability of blood in the thrombus-generator5–7 This instrument, originally described by Chandler, utilizes a revolving loop of plastic tubing into which blood is placed. The clot produced by this procedure has been shown to closely simulate thrombi occurring in human thromboembolic disease; that is, with a white head of platelets and leucocytes and a fibrin tail8–9.
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References
Howell, W. H., Amer. J. Physiol., 31, 1 (1912).
Macfarlane, R. G., Trevan, J. W., and Attwood, A. M. P., J. Physiol. (Lond.), 99, 7, P (1941).
Keys, A., Buzine, R., Grande, F., and Anderson, J. T., Circulation, 15, 274 (1957).
Poole, J. C. F., Brit. J. Exp. Path., 36, 248 (1955).
Poole, J. C. F., Quart. J. Exp. Physiol., 44, 377 (1959).
Connor, W. E., and Poole, J. C. F., Quart. J. Exp. Physiol., 46, 1 (1911).
Connor, W. E., J. Clin. Invest., 41, 1199 (1962).
Chandler, A. B., Lab. Invest., 7, 110 (1958).
Poole, J. C. F., Fed. Proc., 21, 20 (1962).
Shore, P. A., and Alpers, H. S., Amer. J. Physiol., 205, 348 (1963).
Shore, P. A., Alpers, H. S., and Tidball, M. E., Life Sci., 1, 275 (1962).
Shore, P. A., Burkhalter, A., and Cohn, V. H., J. Pharmacol. Exp. Therap., 127, 182 (1959).
Bogdanski, D. F., Pletscher, A., Brodie, B., and Udenfriend, S., J. Pharmacol. Exp. Therap., 117, 82 (1956).
Mibashan, R. S., and Didisheim, P., Fed. Proc., 22, 163 (1963).
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SHORE, P., ALPERS, H. Platelet Damage induced in Plasma by Certain Fatty Acids. Nature 200, 1331–1332 (1963). https://doi.org/10.1038/2001331a0
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DOI: https://doi.org/10.1038/2001331a0
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