Abstract
THE effect of alcohol on the electrical activity of the cortex and deep structures of the brain in various animals has been the subject of investigation of many workers, including Horsey and Akert1 and Caspers2. There is a general agreement that this drug has a synchronizing effect on the spontaneous electrical cortical activity and, depending on the dose of alcohol, shows various degrees of reduction in frequency and decrease in amplitude. The underlying mechanism of this action is still in doubt. Kalant3, in a comprehensive review, quotes Caspers2 and furthers the idea that alcohol exerts its earliest effect at the level of the reticular formation and that the changes in electrical cortical activity are subsequent to the primary reticular depression. In this preliminary communication are presented results on the effects of alcohol on the evoked responses recorded from the reticular formation and cortex following stimulation of the sciatic nerve.
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References
Horsey, W. J., and Akert, K., Quart. J. Studies Alc., 14, 363 (1953).
Caspers, H., Z. gesamte exp. Med., 129, 582 (1958).
Kalant, H., Quart. J. Studies Alc., 22, Supp. No. 1, 1 (1961).
Jasper, H. H., and Marsan, C. Ajmone, A Stereotaxic Atlas of the Diencephalon of the Cat (Nat. Res. Council Canada, 1954).
Morillo, A., and Baylor, D., Electroenceph. Clin. Neurophysiol., 15, 455 (1963).
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DRAVID, A., DI PERRI, R., MORILLO, A. et al. Alcohol and Evoked Potentials in the Cat. Nature 200, 1328–1329 (1963). https://doi.org/10.1038/2001328a0
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DOI: https://doi.org/10.1038/2001328a0
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