Abstract
AN increasing number of clinical and experimental observations suggests that the spleen releases after irradiation an inhibitor of mitosis acting on remote organs and particularly on bone-marrow, but no clear evidence of this hypothetical factor has yet been given1–3. In order to investigate the mechanism of this distant radiological effect, a selective splenic irradiation was carried out on lead-shielded rabbits, and certain hæmatological consequences of this procedure were studied in the blood and bone-marrow. Furthermore, the isolation of an antimitotic factor from the irradiated spleen was attempted.
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References
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MAURICE, P., JEANRENAUD, A. Bone-marrow Mitotic Inhibition induced by Local Splenic X-irradiation. Nature 200, 1221–1222 (1963). https://doi.org/10.1038/2001221a0
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DOI: https://doi.org/10.1038/2001221a0
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