Abstract
PATIENTS with factor VIII deficiency and prolonged skin bleeding time (von Willebrand's syndrome) who receive fresh blood or plasma from normal donors or from patients with hæmophilia A with very low factor VIII activity show a much higher factor VIII activity in their plasma than could possibly be explained by the amounts given. The maximum factor VIII activity is reached 4–8 h after transfusion and persists longer than in hæmophilia A (refs. 1 and 2).
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References
Nilsson, I. M., Blombäck, M., and Blombäck, B., Acta Med. Scand., 164, 263 (1959).
Cornu, P., Larrieu, M. J., Caen, J., and Bernard, J., Nouvelle Rev. Franc. d'Hematologie, 1, 231 (1961).
Blombäck, M., Arkiv. Kemi., 12, 387 (1958). (The material was supplied in dry form by the Commonwealth Serum Laboratories, Melbourne.)
Rizza, C. R., J. Physiol., 156, 128 (1961).
Ingram, G. I. C., J. Physiol., 156, 217 (1961).
Egeberg, O., Scand. J. Clin. Lab. Invest., 14, 475 (1962).
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FANTL, P., SAWERS, R. Stimulation of Factor VIII (Antihæmophilic) Activity by Transfused Serum. Nature 200, 1214–1215 (1963). https://doi.org/10.1038/2001214a0
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DOI: https://doi.org/10.1038/2001214a0
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