Abstract
RECENTLY, Collins has described the presence of ‘complex’ phospholipids in animal tissues1,2. These compounds are shown to be very sensitive towards silicic acid and other mild hydrolytic reagents. This characteristic is believed to be the reason why other workers failed to detect the ‘complex’ phospholipid fraction, since chromatography over silicic acid is universally utilized in the study of phospholipids. Collins defines the complex phospholipids as having a phosphate triester group and structures such as I and II are suggested ; that is, the free hydroxy group on the phosphorus of a ‘normal’ phosphatidyl-choline, -ethanolamine or -serine is esterified with a glycerol moiety. The hydrolysis of these phosphate triesters by chromatography over silicic acid would give rise to ‘normal’ phosphatidyl-choline, -ethanolamine or -serine and the corresponding lyso derivatives; compounds which are identical to those which are actually obtained.
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DE KONING, A. Structure of ‘Complex’ Phospholipids. Nature 200, 1211–1212 (1963). https://doi.org/10.1038/2001211b0
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DOI: https://doi.org/10.1038/2001211b0
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