Inhibition of Pyruvate Metabolism in Mitochondria Suspensions by Cobalt

Abstract

IN a recent publication,, Strickland and Goucher¹ claim that, in brief polarographic experiments, cobalt does not inhibit the oxidation by mitochondrial preparations from rat liver of keto-glutarate, β-hydroxybutyrate or pyruvate. On the basis of these findings, the authors suggest that our observations² on the particular sensitivity of keto-acid oxidation to inhibition by cobalt may have been artefacts caused by prolonged incubation of the mitochondria in the absence of a phosphate acceptor.