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Heterogeneity of Human Intestinal Alkaline Phosphatase

Nature volume 200, pages 1206–1207 (1963)Cite this article

Abstract

INVESTIGATORS who have examined the distribution of alkaline phosphatase after starch-gel electrophoresis of extracts of human small intestine have found the main enzyme activity concentrated in a single, rather diffuse zone in the haptoglobin region, with occasionally one or two minor, slow-moving components also present1–4. Chromatography on substituted cellulose columns has, however, revealed considerable heterogeneity in the main phosphatase peak of some intestinal preparations5,6. In order to resolve this apparent discrepancy between the results with the two techniques, intestinal phosphatase fractions obtained by column chromatography have now been compared directly with those seen on starch gels.

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Authors and Affiliations

  1. Department of Chemical Pathology, Postgraduate Medical School of London, Ducane Road, London, W.12

    D. W. MOSS

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  1. D. W. MOSS
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MOSS, D. Heterogeneity of Human Intestinal Alkaline Phosphatase. Nature 200, 1206–1207 (1963). https://doi.org/10.1038/2001206a0

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