Abstract
MUCH of the available experimental evidence1,2 suggests that pathological demyelination in the human brain might occur as a result of a delayed-type hypersensitivity reaction against myelin3,4, although a significant role of circulating antibody cannot be altogether ruled out5,6. Previously7,8 we reported that we had been able to elicit a skin reaction against proteolipid A derived from human brain in 21 cases of multiple sclerosis and two patients with clinically diagnosed neuroses which was in agreement with the results obtained by other investigators9,10 who had tested skin reactivity against unpurified human myelin. While the pathognomonic significance of the skin reaction thus remains doubtful we endeavoured to examine the question whether a true hypersensitivity reaction was present or not by comparing a large number of adult patients with a group of children suffering from a variety of central nervous system disorders as to their ability to react against myelin.
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BÖHME, D., PAAL, G., KERSTEN, W. et al. Skin Reaction in Children and Adults with Central Nervous System Disease after Intracutaneous Administration of Myelin Preparations derived from Human Brain. Nature 199, 84–85 (1963). https://doi.org/10.1038/199084a0
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DOI: https://doi.org/10.1038/199084a0
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