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Changes in Resistance to the Proliferation of Isotransplanted Gross Virus-induced Lymphoma Cells, as measured with a Spleen Colony Assay

Nature volume 199, pages 80–83 (1963)Cite this article

Abstract

KLEIN et al.1 have shown that a state of relative resistance against the isotransplantation of Gross virus-induced lymphomas could be built up in C3H mice by treatment with cells from lymphomas originally induced by the same virus. Sera from such resistant mice were shown by Slettenmark and Klein2 to be cytotoxic in vitro for the cells of many Gross virus-induced lymphomas. These findings suggested that lymphomas induced by Gross virus possess tumour-specific antigen, and furthermore that the same antigen is present on the cells of all or most lymphomas induced by this virus.

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Authors and Affiliations

  1. Division of Biological Research, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto,

    A. A. AXELRAD

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  1. A. A. AXELRAD
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AXELRAD, A. Changes in Resistance to the Proliferation of Isotransplanted Gross Virus-induced Lymphoma Cells, as measured with a Spleen Colony Assay. Nature 199, 80–83 (1963). https://doi.org/10.1038/199080a0

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