Abstract
γ1A-GLOBULIN (β2A-globulin) is progressively gaining recognition as representing a third type of immune globulin, besides the γss− (γ2−, 7Sγ−) and γ1M− (19Sγ−, β2M−) globulin classes1–3. This concept was at first based on the structural relationship between these three protein groups, as well as on their simultaneous deficiency in con genital agammaglobulinæmia, and on the occurrence of three corresponding types of paraproteinæmias. Recently, specific anti body activities have been reported to be associated with purified γ1A samples isolated from human sera4,5.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Heremans, J. F., Les globulines sériques du système gamma (Masson, Paris; Arscia, Brussels, 1960).
Schultze, H. E., Clin. Chim. Acta, 4, 610 (1959).
Franklin, E. C., Vox Sanguinis, 7, 1 (1962).
Heremans, J. F., Vaerman, J.-P., and Vaerman, Cl., J. Immunol., 91 (in the press).
Heremans, J. F., and Vaerman, J.-P., Nature, 193, 1091 (1962).
Asofsky, M. D., and Thorbecke, G. J., J. Exp. Med., 114, 471 (1961).
Paraskevas, F., Heremans, J. F., and Waldenström, J., Acta Med. Scand., 170, 575 (1961).
Burtin, P., in Cellular Aspects of Immunity, Ciba Found. Symp., 213 (Churchill, London, 1960).
Ortega, L. G., and Mellors, R. C., J. Exp. Med., 106, 607 (1957).
Vazquez, J. J., Lab. Invest., 10, 1110 (1961).
Mellors, R. C., Heimer, R., Corcos, J., and Korngold, L., J. Exp. Med., 110, 875 (1959).
Leduc, E. H., Coons, A. H., and Connolly, J. M., J. Exp. Med., 102, 61 (1955).
White, R. G., in Mechanisms of Antibody Formation, 25 (Czech. Acad. Sci., Prague, 1960).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
CARBONARA, A., RODHAIN, J. & HEREMANS, J. Localization of γIAGlobulin (β2A-Globulin) in Tissue Cells. Nature 198, 999–1000 (1963). https://doi.org/10.1038/198999a0
Issue Date:
DOI: https://doi.org/10.1038/198999a0
This article is cited by
-
Die optische Rotationsdispersion isolierter Paraproteine
Klinische Wochenschrift (1966)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.