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Localization of γIAGlobulin (β2A-Globulin) in Tissue Cells

Abstract

γ1A-GLOBULIN (β2A-globulin) is progressively gaining recognition as representing a third type of immune globulin, besides the γss−2−, 7Sγ−) and γ1M− (19Sγ−, β2M) globulin classes1–3. This concept was at first based on the structural relationship between these three protein groups, as well as on their simultaneous deficiency in con genital agammaglobulinæmia, and on the occurrence of three corresponding types of paraproteinæmias. Recently, specific anti body activities have been reported to be associated with purified γ1A samples isolated from human sera4,5.

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References

  1. Heremans, J. F., Les globulines sériques du système gamma (Masson, Paris; Arscia, Brussels, 1960).

    Google Scholar 

  2. Schultze, H. E., Clin. Chim. Acta, 4, 610 (1959).

    Article  CAS  Google Scholar 

  3. Franklin, E. C., Vox Sanguinis, 7, 1 (1962).

    Article  CAS  Google Scholar 

  4. Heremans, J. F., Vaerman, J.-P., and Vaerman, Cl., J. Immunol., 91 (in the press).

  5. Heremans, J. F., and Vaerman, J.-P., Nature, 193, 1091 (1962).

    Article  ADS  CAS  Google Scholar 

  6. Asofsky, M. D., and Thorbecke, G. J., J. Exp. Med., 114, 471 (1961).

    Article  CAS  Google Scholar 

  7. Paraskevas, F., Heremans, J. F., and Waldenström, J., Acta Med. Scand., 170, 575 (1961).

    Article  CAS  Google Scholar 

  8. Burtin, P., in Cellular Aspects of Immunity, Ciba Found. Symp., 213 (Churchill, London, 1960).

    Google Scholar 

  9. Ortega, L. G., and Mellors, R. C., J. Exp. Med., 106, 607 (1957).

    Article  Google Scholar 

  10. Vazquez, J. J., Lab. Invest., 10, 1110 (1961).

    PubMed  CAS  Google Scholar 

  11. Mellors, R. C., Heimer, R., Corcos, J., and Korngold, L., J. Exp. Med., 110, 875 (1959).

    Article  CAS  Google Scholar 

  12. Leduc, E. H., Coons, A. H., and Connolly, J. M., J. Exp. Med., 102, 61 (1955).

    Article  CAS  Google Scholar 

  13. White, R. G., in Mechanisms of Antibody Formation, 25 (Czech. Acad. Sci., Prague, 1960).

    Google Scholar 

Download references

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CARBONARA, A., RODHAIN, J. & HEREMANS, J. Localization of γIAGlobulin (β2A-Globulin) in Tissue Cells. Nature 198, 999–1000 (1963). https://doi.org/10.1038/198999a0

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