Abstract
McILWAiN et al. have established that the content of extractable gangliosides (measured by their N-acetyl-neuraminic acid moiety) is directly related to the excit ability of the nervous tissue1. The N-acetylneuraminic acid is suggested to form a hydrophilic path for the passage of cations through the lipid membrane2. We wished to check whether the decreased metabolic response of rat brain cortex slices to electrical stimulation during ethanol intoxication3 could be accounted for by a decrease in the N-acetylneuraminic acid groups available.
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References
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HÁKKINEN, HM., KULONEN, E. Content of Extractable Gangliosides in Rat Brain during Ethanol Intoxication. Nature 198, 995 (1963). https://doi.org/10.1038/198995b0
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DOI: https://doi.org/10.1038/198995b0
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