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Specific Acetylcholine Acyl-hydrolases of Sheep Brain

Nature volume 198, pages 884–885 (1963)Cite this article

Abstract

UNLIKE the acetylcholine acyl-hydrolases (‘cholinesterases’) of mammalian blood, those of mammalian brain have received relatively little attention. Both the specific activities1,2 and protein content are low; and the high factors of purification obtainable with material from electric organs2,3 could not be achieved in the case of brain from rat1,4–6, pig7, rabbit or calf8. The highest specific activity (in units of µl. carbon dioxide/h/mg protein, at 37° in our manometric experiments) reported appears to be 765 in the case of rabbit brain8. Preparations from sheep brain with higher specific activities are the subject of this communication.

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Authors and Affiliations

  1. Department of Chemistry, University of Tasmania, Hobart

    KATALIN GOT & J. B. POLYA

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  1. KATALIN GOT
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  2. J. B. POLYA
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GOT, K., POLYA, J. Specific Acetylcholine Acyl-hydrolases of Sheep Brain. Nature 198, 884–885 (1963). https://doi.org/10.1038/198884a0

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