Abstract
IN a previous communication1, it was reported that fluorescein-tagged serum globulin collected in the postpartum period of normal human pregnancies localizes in syncytiotrophoblastic cytoplasm of the placenta delivered by the patient in a manner best interpreted as an antigen–antibody reaction. This communication was based on five patients from whom the serum was collected on the fourth postpartum day. This day was arbitrarily chosen because of the theoretical possibility that antibodies formed during pregnancy might be absorbed by the large volume of trophoblastic material present in the placenta, hence might not be present in significant amounts in the circulation prior to delivery.
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References
Hulka, J. F., Hsu, K. C., and Beiser, S. M., Nature, 187, 707 (1960).
Coons, A. H., and Kaplan, M. H., J. Exp. Med., 91, 1 (1950).
Benson, R. C., Obstet. Gynecol., 5, 639 (1962).
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HULKA, J., BRINTON, V., SCHAAF, J. et al. Appearance of Antibodies to Trophoblast during the Postpartum Period in Normal Human Pregnancies. Nature 198, 501–502 (1963). https://doi.org/10.1038/198501a0
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DOI: https://doi.org/10.1038/198501a0
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