Abstract
AN early test for possible skin carcinogens in the mouse has been reported1. The test is based on a tetrazolium reduction method. It was demonstrated that the test could reveal the carcinogens in a blind test of 21 substances of which seven were carcinogens2, and that a complete correlation existed between the results of the test and the yield of tumour after a single application of different doses of 3-methylcholanthrene3.
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Iversen, O. H., Nature, 192, 273 (1961).
Iversen, O. H., and Evensen, A., Acta Path. and Microbiol. Scand., Supp. 156 (1962).
Iversen, O. H., Nature, 196, 181 (1962).
Bock, F. G., and Mund, R., Cancer Res., 18, 886 (1958).
Baldwin, R. W., Cunningham, G. J., and Partridge, M. W., Brit. J. Cancer, 13, 94 (1959).
Baldwin, R. W., Cunningham, G. J., Partridge, M. W., and Vipond, H. J., Brit. J. Cancer, 16, 275 (1962).
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IVERSEN, O. An Early Test for Possible Skin Carcinogens in the Mouse: Effects of a Benzacridine and of some Tricycloquinazolines. Nature 198, 400 (1963). https://doi.org/10.1038/198400a0
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DOI: https://doi.org/10.1038/198400a0
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