Abstract
THE method of Tishler et al.1 for the synthesis of naphthotocopherol consistently yielded a product contaminated with as much as 5 per cent of naphthotoco-pheryl acetate. The contaminant was detected by infrared spectroscopy and was isolated by thin-layer chromatography2. Since thin-layer chromatographic purification was not suitable for preparing sufficient quantities of the naphthotocopherol for investigations in biological systems, the method reported here was developed.
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References
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Dallam, R. D., Biochem. and Biophys. Res. Comm., 4, 106 (1961).
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CHEN, L., DALLAM, R. Synthesis of Naphthotocopherol. Nature 198, 386 (1963). https://doi.org/10.1038/198386a0
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DOI: https://doi.org/10.1038/198386a0
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