Abstract
ALTHOUGH the precise steps in chemical carcinogenesis are completely unknown, a stable interaction with some cellular component may well be an essential primary event in the process leading to malignancy. The binding of aminoazo dyes and polycyclic hydrocarbons to tissue proteins has been extensively investigated by the Millers1 and by Heidelberger et al.2. With chemical compounds of this type, there appears to be a correspondence between the degree of protein binding and the ability of an agent to function as a carcinogen.
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References
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Heidelberger, C., in Ciba Symp. Carcinogenesis, edit. by Wolstenholme, G. E. W., and O'Connor, M., 179 (Little, Brown and Co., Boston, 1959).
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For reviews, see Mosinger, M., Bull. du Cancer, 48, 546 (1961). Blumenthal, H. T., and Rogers, J. B., Cancer Res., 22, 1155 (1962).
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OLD, L., BENACERRAF, B. & CARSWELL, E. Contact Reactivity to Carcinogenic Polycyclic Hydrocarbons. Nature 198, 1215–1216 (1963). https://doi.org/10.1038/1981215a0
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DOI: https://doi.org/10.1038/1981215a0
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