Abstract
AN elaborate hierarchy of elements of structure and control in the genetic material has been proposed by Jacob and Monod1,2 and their collaborators as the genetic basis for the synthesis of β-galactosidase in E. coli. According to their concept, which is supported by considerable experimental data for this and other bacterial systems3,4, the amino-acid sequence of a protein is determined by a particular genetic locus (the structural gene). Synthesis of the protein is initiated by an operator gene, which may be either closely linked to the structural gene or a part of the structural gene; the initiating function of the operator gene is controlled by a regulator gene, which determines the synthesis of a represser. The represser acts through the cytoplasm to inhibit the operator gene.
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PARKER, W., BEARN, A. Control Gene Mutations in the Human Haptoglobin System. Nature 198, 107–108 (1963). https://doi.org/10.1038/198107a0
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DOI: https://doi.org/10.1038/198107a0
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