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Lysosomes and Vacuolation of the Liver Cell

Nature volume 198, pages 1015–1016 (1963)Cite this article

Abstract

VACUOLATION of the liver cell can be produced by a variety of experimental procedures such as intravenous or intraperitoneal injection of hypertonic solutions1, or anoxia2. The vacuoles do not contain any material detectable by ordinary histological methods and hence have been referred to as ‘watery vacuolation’. Aterman suggests that the vacuoles he studied, produced by injection of hypertonic solutions, result from uptake by the liver cell of substances from the blood. Hanzon3 and Reese4, examining anoxic vacuolation, thought they were derived from bile canaliculi. In this communication we describe vacuoles in the liver cell developing from lysosomes.

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Authors and Affiliations

  1. Department of Pathology, University of Birmingham,

    D. B. BREWER & D. HEATH

Authors
  1. D. B. BREWER
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  2. D. HEATH
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BREWER, D., HEATH, D. Lysosomes and Vacuolation of the Liver Cell. Nature 198, 1015–1016 (1963). https://doi.org/10.1038/1981015b0

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  • DOI: https://doi.org/10.1038/1981015b0

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