Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Action of γ-Aminobutyric Acid on Cancer borealis Muscle

Nature volume 198, pages 1002–1003 (1963)Cite this article

Abstract

IN several crayfish preparations1–5 γ-aminobutyric acid (GABA) mimics the natural inhibitory transmitter. Moreover, it has recently been found in large amounts in Cancer borealis peripheral nerve and muscle6, suggesting a possible role as inhibitory transmitter. The action of GABA on C. borealis muscle has not been examined. It has been reported that GABA has no inhibitory effect on C. anthonyi muscle7 and that it blocks excitatory junctional potentials in C. magister muscle while scarcely changing membrane conductance8. Thus, it seemed of interest to investigate the action of GABA on C. borealis muscle.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Boistel, J., and Fatt, P., J. Physiol., 144, 176 (1958).

    Article  CAS  Google Scholar 

  2. Edwards, C., and Kuffler, S. W., J. Neurochem., 4, 19 (1959).

    Article  CAS  Google Scholar 

  3. Kuffler, S. W., and Edwards, C., J. Neurophysiol., 21, 589 (1958).

    Article  CAS  Google Scholar 

  4. Dudel, J., and Kuffler, S. W., J. Physiol., 155, 543 (1961).

    Article  CAS  Google Scholar 

  5. Hagiwara, S., Kusano, K., and Saito, S., J. Neurophysiol., 23, 505 (1960).

    Article  CAS  Google Scholar 

  6. Kravitz, E. A., Potter, D. D., and van Gelder, N. M., Nature, 194, 382 (1962).

    Article  ADS  CAS  Google Scholar 

  7. Hoyle, G., and Wiersma, C. A. G., J. Physiol., 143, 426 (1958).

    Article  CAS  Google Scholar 

  8. Florey, E., and Hoyle, G., in Nervous Inhibition, edit. by Florey, E (Pergamon Press, 1961).

    Google Scholar 

  9. Fatt, P., and Katz, B., J. Physiol., 121, 374 (1953).

    Article  CAS  Google Scholar 

Download references

Author information

Author notes

  1. ROBERT S. EISENBERG

    Present address: Department of Biophysics, University College, London

  2. DAVID HAMILTON

    Present address: Institute of Physiology, University of Glasgow,

Authors and Affiliations

  1. Nerve-Muscle Progrom, Marine Biological Laboratory, Woods Hole, Mass.

    ROBERT S. EISENBERG & DAVID HAMILTON

Authors
  1. ROBERT S. EISENBERG
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. DAVID HAMILTON
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

EISENBERG, R., HAMILTON, D. Action of γ-Aminobutyric Acid on Cancer borealis Muscle. Nature 198, 1002–1003 (1963). https://doi.org/10.1038/1981002b0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/1981002b0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing