Abstract
IT is well known that insulin stimulates the synthesis of glycogen in isolated muscle tissue from different animals. Insulin is considered to increase the permeability of the cell membrane to glucose. Direct action on the enzymes responsible for the synthesis of glycogen has also been observed. Low muscle glycogen has been found in animals with experimental diabetes. There are, however, few reports on the muscle glycogen content in normal and diabetic man. The glycogen content in muscle biopsy specimens from normal subjects was investigated by Hildes et al.1–3 and by Nichols4. Hildes et al.2,3 also determined the glycogen content in muscle tissue from patients with diabetes. No significant decrease was found in the muscle glycogen compared with the normal subjects. Their patients were adults who, in most cases, had been treated with insulin up to a few days before the examination.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Hildes, J. A., Purser, S. H., and Sherlock, S., J. Physiol., 109, 232 (1949).
Hildes, J. A., Sherlock, S., and Walshe, V., Clin. Sci., 7, 287 (1949).
Hildes, J. A., Sherlock, S., and Walshe, V., Clin. Sci., 7, 297 (1949).
Nichols, N., J. Clin. Invest., 34, 1710 (1955).
Bergström, J., Scand. J. Clin. Lab. Invent., 14, Supp. 68, 110 (1962).
Hultman, E., Nature, 183, 108 (1959).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BERGSTRÖM, J., HULTMAN, E. & ROCH-NORLUND, A. Muscle Glycogen in Juvenile Diabetes before and during Treatment with Insulin. Nature 198, 97–98 (1963). https://doi.org/10.1038/198097b0
Issue Date:
DOI: https://doi.org/10.1038/198097b0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.