Abstract
DRS. C. Kidson and J. G. Gorman1 report observations on frequencies of glucose-6-phosphate dehydrogenase (G6PD) deficiency in different parts of New Guinea and New Britain, which make a welcome addition to our knowledge of the population genetics of this area. They note that low frequencies of G6PD deficiency occur in some populations living in malarious parts of New Guinea, New Britain and elsewhere. On the basis of this fact, and a report2 suggesting that “no significant difference in Pl. falciparum parasite densities occurs between affected and normal children under 3 years of age in Thailand and that affected children in this age-group may have higher densities of the non-lethal Pl. vivax”, Kidson and Gorman issue “a challenge to the concept of selection by malaria in glucose-6-phosphate dehydrogenase deficiency”.
Similar content being viewed by others
Article PDF
References
Kidson, C., and Gorman, J. G., Nature, 196, 49 (1962).
Kruatrachue, M., and Harinasuta, C., presented at the Tenth Pacific Sci. Conf. Honolulu (1961).
Allison, A. C., Ann. N.Y. Acad. Sci., 91, 710 (1961).
Fisher, R. A., The Genetical Theory of Natural Selection (Oxford, 1930). Bennett, J. H., Austral. J. Biol. Sci., 11, 598 (1958). Parsons, P. A., Heredity, 16, 103 (1961).
Siniscalco, M., Bernini, L., Latte, B., and Motulsky, A. G., Nature, 190, 1179 (1961).
Motulsky, A. G., Human Biol., 32, 28 (1960).
Allison, A. C., Nature, 186, 531 (1960).
Allison, A. C., and Clyde, D. F., Brit. Med. J., i, 1346 (1961).
Gilles, H. M., and Taylor, B. G., Ann. Trop. Med. Parasitol., 55, 64 (1961).
Harris, R., and Gilles, H. M., Ann. Hum. Genet., 25, 199 (1961).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
ALLISON, A. Malaria and Glucose-6-phosphate Dehydrogenase Deficiency. Nature 197, 609 (1963). https://doi.org/10.1038/197609a0
Issue Date:
DOI: https://doi.org/10.1038/197609a0
This article is cited by
-
Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study
Malaria Journal (2020)
-
Report of an Italian family carrying a typical Indian variant of the Nilgiris tribal groups resulting from a de novo occurrence
Human Genome Variation (2018)
-
Association of glucose-6-phosphate dehydrogenase deficiency and malaria: a systematic review and meta-analysis
Scientific Reports (2017)
-
Erythrocyte G-6-PD and 6-PGD genetic polymorphisms in South African Negroes, with a note on G-6-PD and the malaria hypothesis
Human Genetics (1980)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.