Abstract
IT has been shown that the antigenic structure of tumours and of the corresponding normal tissues is different1. Specific antigens were demonstrated in spontaneous, induced and transplanted tumours of mice, rat, rabbits and chickens, as well as in various human tumours by the method of anaphylactic reaction following desensitization. By means of the gel diffusion of Ouchterlony, Zilber et al.2 were able to show an antigen in extracts from a mice hepatoma lacking in normal liver. We were able to confirm this work in a tumour of the rat; we obtained a specific antigen present in the granular fraction of a transplantable hepatoma.
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Zilber, L. A., Acta Union Intern. Cancer, 17, 244 (1959).
Zilber, L. A., Il Cancro, 14, 458 (1961).
Deckers, C., and Maisin, J., Revue belge de Pathologie et de Médecine expérimentale, 27, 477 (1961).
Leonardi, P., Zerbinato, A., and Audolfatto-Zaglia, O., Boll. ist. sieroter. milan., 35, 613 (1956).
Ambrosino, C., Liberatori, J., Paolino, W., Calciati, A., and Ricci, C., Atti del VII Cong. Soc. Intern. Ematologia, Roma (1958).
Peetom, F., Rose, N., Ruddy, S., Micheli, A., and Grabar, P., Ann. Inst. Pasteur, 98, 252 (1960).
Metzgar, R. S., and Grace, J. T., J. Immunol., 86, 578 (1961).
Tomasi, T. B., J. Immunol., 86, 427 (1961).
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DECKERS, C., MAISIN, J. Non-specific Precipitation Patterns obtained in Double Diffusion between Serum and Extracts of Normal Organs and Tumours. Nature 197, 397 (1963). https://doi.org/10.1038/197397a0
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DOI: https://doi.org/10.1038/197397a0
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