Abstract
ERYTHROCYTE antibodies were first demonstrated by their ability to agglutinate erythrocytes suspended in saline; these have been termed complete antibodies. In 1944, Wiener1 and Race2 independently showed that certain erythrocyte antibodies were incomplete, possessing the ability to fix to the erythrocyte surface without leading to agglutination. It has been postulated1, and generally accepted, that the complete saline agglutination antibody is bivalent, and the incomplete coating antibody univalent. Recent investigations in our laboratory using antibodies labelled with iodine-131 have led us to question this hypothesis3,4. Our results could best be explained by assuming a bivalent nature of incomplete erythrocyte antibodies.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Wiener, A. S., Proc. Soc. Exp. Biol. and Med., 56, 173 (1944).
Race, R. R., Nature, 153, 771 (1944).
Pirofsky, B., Cordova, M., and Imel, T., Vox Sang., 7, 348 (1962).
Pirofsky, B., Cordova, M., and Imel, T., J. Immunol., 89, 767 (1962).
Fudenberg, H. H., and Kunkel, H. G., J. Exp. Med., 106, 689 (1957).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
PIROFSKY, B., SOLEDAD CORDOVA, M. Bivalent Nature of Incomplete Anti-D(Rho). Nature 197, 392–393 (1963). https://doi.org/10.1038/197392b0
Issue Date:
DOI: https://doi.org/10.1038/197392b0
This article is cited by
-
Die Eluierung inkompletter Antikörper von Erythrozyten
Blut Zeitschrift für die Gesamte Blutforschung (1966)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
