Abstract
THE fall in intra-ocular pressure in patients with glaucoma simplex following topical epinephrine therapy has been noted repeatedly1–3. Recent tonographic analysis related this effect primarily to an increase in the facility of aqueous outflow although initially some small reduction in aqueous secretion may take place4–6. The mechanism by which the change in facility occurs is not known. Since tissues chronically deprived of their effector nerves develop an increased sensitivity to the neurohumoral transmitter, denervation experiments were performed to investigate the specificity of the response of outflow resistance to adrenergic influences.
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SEARS, M., SHERK, T. Supersensitivity of Aqueous Outflow Resistance in Rabbits after Sympathetic Denervation. Nature 197, 387–388 (1963). https://doi.org/10.1038/197387a0
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DOI: https://doi.org/10.1038/197387a0
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