Abstract
PROLONGED clotting and prothrombin times as a function of lower blood temperature have been observed in various species in vivo1–4 and in vitro5. The in vivo observations were made in aestivating and hibernating mammals2–4 and with human blood from blood vessels where a differential in temperature had been demonstrated1. By contrast, Tadzer6, using the rat in a study of hypothermia of short duration and uncomplicated by shock, did not find prolonged thrombin times; Lasch et al.7, working with dogs, even obtained shorter clotting times on cooling, and a prolongation, due to an increase in heparin, on rewarming.
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GRIMINGER, P., WEISS, H. & HOLLANDS, K. Coagulation of Blood in Temperature Acclimatization. Nature 197, 1118 (1963). https://doi.org/10.1038/1971118a0
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DOI: https://doi.org/10.1038/1971118a0
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