Abstract
THE ability of the mucosa of the gastrointestinal tract to form glucuronides has been previously reported1–3. The function of such conjugate formation in the intestinal mucosa has not yet been clarified. It has been variously suggested that glucuronide formation by this tissue may play an important part in detoxification3, in mucopolysaccharide formation4, or in the absorption of various substances from the intestinal lumen5,6. A genetically determined deficiency of the enzyme responsible for the transfer of glucuronic acid from uridine diphosphate glucuronic acid (UDPGA) to various acceptors has been detected in the livers of homozygous Gunn rats7,8. The work reported here was undertaken to determine whether there is a similar deficiency of this enzyme (UDP transglucuronylase) in the intestine of the Gunn rat. The results provide further evidence for the similarity between glucuronide synthesis in the intestinal mucosa and liver3 and for the importance of glucuronide formation in the transport of various substances by rat intestine in vitro.
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ARIAS, I., FURMAN, M., TAPLEY, D. et al. Glucuronide Formation and Transport of Various Compounds by Gunn Rat Intestine in vitro. Nature 197, 1109–1110 (1963). https://doi.org/10.1038/1971109a0
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DOI: https://doi.org/10.1038/1971109a0
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