Abstract
THE application of the Peltier effect in the preparation of frozen histological sections has been described by Ioffe1and Brown and Dilly2, who cooled the microtome stage by means of thermoelements constructed of semi-conductor materials. Sections of fixed material can be obtained in this way; but it is not possible to cut sections of fresh unfixed tissue by merely cooling the microtome stage. For this purpose it is necessary to cool not only the stage, but also the knife, and although this can be done with solid carbon dioxide the method is not very satisfactory.
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References
Ioffe, A. F., Semiconductor Thermoelements and Thermoelectric Cooling (Infosearch, Ltd., London, 1957).
Brown, R., and Dilly, M., J. Physiol., 161, No. 1 (1962).
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HARDY, W., RUTHERFORD, T. Thermoelectric Apparatus for the Preparation of Fresh-Frozen Tissue Sections. Nature 196, 785–786 (1962). https://doi.org/10.1038/196785a0
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DOI: https://doi.org/10.1038/196785a0
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