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Central Respiratory Chemo-sensitivity and its Relationship to Peripheral Nerve Carbon Dioxide-sensitivity

Nature volume 196, pages 779–780 (1962)Cite this article

Abstract

BECAUSE ventilation is proportional to the alveolar pCO2it is generally assumed that carbon dioxide has a direct excitatory effect on either the neurones in the ‘respiratory centre’1or on a ‘special chemo-receptor system’ independent of the synapses in the respiratory reflex pathways2. An examination of the effect of carbon dioxide on the excitability of peripheral nerve suggests, however, another possible explanation. This has been investigated in ‘normal’ subjects in whom the alveolar carbon dioxide tensions were changed experimentally3.

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Author notes

  1. I. P. PRIBAN

    Present address: Medical Research Council, Pneumoconiosis Research Unit, Llandough Hospital, Penarth, Glamorgan

Authors and Affiliations

  1. Institute of Neurology, The National Hospital, Queen Square, London, W.C.1

    I. P. PRIBAN

Authors
  1. I. P. PRIBAN
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PRIBAN, I. Central Respiratory Chemo-sensitivity and its Relationship to Peripheral Nerve Carbon Dioxide-sensitivity. Nature 196, 779–780 (1962). https://doi.org/10.1038/196779a0

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