Abstract
ALTHOUGH the derivation of serum protein secreting plasma cells and of macrophages from a common immature mesenchymal cell is accepted, it has become customary to differentiate sharply macrophages from lymphoid cells, particularly plasma cells1,2. Electron microscopically, the macrophage is characterized by numerous vacuoles of various sizes or phagosomes containing granular material with differing electron densities3. It also contains occasional profiles of endoplasmic reticulum with ribonucleoprotein particles4. In contrast, the plasma cell is filled with an elaborate system of lamellæ of endoplasmic reticulum lined by ribosomes4,5. This is considered a protein secretory mechanism and immunofluorescence studies have shown this to be γ-globulin6.
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SCHAFFNER, F., POPPER, H. A Phagocytic and Protein-forming Mesenchymal Cell in Human Cirrhosis. Nature 196, 684–685 (1962). https://doi.org/10.1038/196684a0
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DOI: https://doi.org/10.1038/196684a0
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