Abstract
RECENT investigations1,2 have shown that acetylcholine in the central nervous system is located within cell particles which have been identified as pinched-off nerve endings. It was of interest to determine whether other substances which may act as transmitters, or as regulators of neuronal excitability, would have a similar sub-cellular distribution. Therefore we have determined the sub-cellular distribution of acetylcholine-, substance P- and 5-hydroxytryptamine (5-HT)-like substances and also of glutamic acid and γ-aminobutyric acid (GABA).
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RYALL, R. Sub-cellular Distribution of Pharmacologically Active Substances in Guinea Pig Brain. Nature 196, 680–681 (1962). https://doi.org/10.1038/196680a0
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DOI: https://doi.org/10.1038/196680a0
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